Preparation and evaluation of sustained release matrix tablet of diclofenac sodium using natural polymer gnkganesh , rsureshkumar, njawahar ,v senthil ,dnagasamy venkatesh and m shanmukha srinivas department of pharmaceutics,jss college of pharmacy, ooty, tamilnadu-643001, india abstract. Trazodone hydrochloride controlled release matrix and matrix-mini tablets by kiran penuma tcha a thesis submitted in partial fulfillment of the requirement for the degree of master of science in applied pharmaceutical sciences university of. Shaikh r, msc thesis, “design and evaluation of controlled release layered matrix tablets of paracetamol and verapamil hcl” university of malaysia, march 2009 4 kadri bv, msc thesis, “mechanism of drug release from matrix tablets involving moving boundaries” university of toronto, november 2001. Manufacturing of matrix tablets by combining countercharged poly(meth)acrylate polymers to provide sustained release of highly soluble drugs inaugural- dissertation zur erlangung des doktorgrades der mathematisch- naturwissenschaftlichen fakultät der heinrich-heine-universität düsseldorf vorgelegt von. Full-text (pdf) | extended release oral matrix formulations of metoprolol succinate : development and in vitro evaluation thesis for: mpharm, advisor: mr a k srivastava cite this publication abstracts: the objective of this study was to develop sustained release matrix tablets of metoprolol succinate.
Thesis i van veen b, pajander j, zuurman k, lappalainen r, poso a, frijlink hw, ketolainen j: the effect of powder blend and tablet structure on drug release mechanisms of hydrophobic starch acetate matrix tablets european journal of pharmaceutics and biopharmaceutics 61: 149-157, 2005 ii pajander j, van. 11 objective of the present work the title of the thesis is formulation and evaluation of sustained release matrix tablets of aceclofenac and its pharmacokinetic and pharmacodynamic studies in animal model aceclofenac is a synthetic non- steroidal anti- inflammatory drug. Profiles phd thesis shi qiu this thesis is submitted in partial fulfilment of the requirements of de montfort university for the award of doctor of philosophy cin cocrystals in hpmc based matrix tablets chapter 7 role of polymers in solution and tablet based carbamazepine cocrystal formulations.
Publications and presentations related to the thesis 1 sz pál, s nagy application of weibull distribution for investigation of controlled release matrix tablets 1 matrix and in the 2 coating figure 1 basic types of pellets (matrix pellet containing api on the left inert pellet core with layer containing the api on the right. The matrix tablets were prepared by the wet granulation method and evaluated for pharmacopoeial requirements tkp2 was the optimum formulation as it had a short floating lag time (flt 30 s) and more than 985% drug release in 12 h the dissolution data were fitted to popular mathematical models to. The study was aimed at developing extended release matrix tablets of poorly water-soluble diclofenac sodium and highly water-soluble metformin hydrochloride by direct compression using cashew gum, xanthan gum and hydroxypropylmethylcellulose (hpmc) as release retardants the suitability of light grade cashew.
A homologous series of aliphatic organic salts influenced solution and matrix properties in rank order of hydrocarbon chain length monovalent salts containing 1 t04 c-atoms had little effect on polymer surface activity, but lowered sol:gel transition temperatures (sgtt), and accelerated matrix drug release in comparison. Kollidon® sr were evaluated for application in extended release matrix tablets the effects of the following formulation and process variables on tablet properties and drug release were tested: kollidon® sr concentration in the tablet, addition of external binder for wet granulation, presence of an enteric.
The present thesis intended to analyze drug release mechanisms from two different types of extended release dosage forms, namely coated tablets and matrix devices regarding coated tablets it is possible to modify the drug release by the application of polymer coats which determine either ph-dependent or ph-. Scope of the thesis 13 objective vii ix 14 literahire review 141 matrix tablets 4 1 42 mechanism of drug release from swellable matrix tablets 5 143 polymers and disintegrants 10 144 drug solubility 145 swelling and diffusion fronts in mabix tablets 146 methods used to snidy swelling kinetics 15 re ferences. Studied the dome shaped matrix showed different drug release compared to a cylindrical matrix having the same composition and mass the thesis also showed by certain production problems that may be connected with production , such as compression force, and polymer coating of drugs or tablets in this thesis the.
Hcl matrix tablets were prepared using different polymers like carbopol 971 xanthan gum, hydroxypropyl methyl key words: sustained release drug delivery system, matrix tablets, metformin hydro- chloride, hpmc prolonged release gliclazide matrix tablets “ thesis submitted in fulfillment of the requirements for. Formulation and in-vitro evaluation of oral sustained-release diclofenac sodium matrix tablets using hydrophilic polymer blends a thesis submitted in fulfillment of the requirements for the degree of master of philosophy (pharmaceutics) in the.